Although it is a part of traditional medicine, big sagebrush is seldom used for medicinal purposes. In effect, big sagebrush encloses an unsteady or volatile oil that may be added in the form of an aromatic to liqueurs as well as hair rinses. In addition, the oil extracted from big sagebrush is also used as a repellent for bugs. Big sagebrush is known to cause extreme allergic reaction in humans and may even result in dermatitis if it is topically applied to the skin of sensitive people. On the other hand, the volatile oils enclosed by this herb are metabolized in the liver to form toxic compounds that have the potential to cause internal blood clotting. In addition, it may also result in the formation of micro-thrombi in the digestive tract and the liver. The indigenous people of the North America traditionally used the big sagebrush internally as a medication to stop internal hemorrhage that may be a result of childbirth or wounds sustained during a battle. The big sagebrush plant is also poisonous for parasites inside the body and, hence, it was also used to get rid of worms. As aforementioned, the oils extracted from the plant are noxious to the liver as well as the digestive system of the humans when they are taken internally. However, usually, the toxic symptoms of the big sagebrush sink within 24 hours to 48 hours of ingesting the plant. Native Americans inhabiting the Mountain West in North America also used an herbal tea prepared from big sagebrush which was earlier used internally and also as an external dressing to cure infections. In the ancient times, parts of the big sagebrush plant were also woven to make footwear. An infusion prepared with the big sagebrush leaves is still used as a hair rinse and it is known to cure dandruff as well as falling hair. The infusion of this herb is also said to work as a disinfectant and, hence, it is used for washing walls, floor and so on. The leaves, buds and stems of big sagebrush together also yield a dye whose color varies from yellow to gold. The bark of the bush is fibrous and, hence, is excellent for weaving mats, basket and even clothes. Some people also use the dried fibrous bark of the plant as a stuffing material in pillows and such objects. In addition, the fibrous bark of big sagebrush is also used in the form of insulation in shoes to keep the feet warm. On the other hand, the fiber obtained from the inner bark of the sagebrush shrub is used for manufacturing paper. The fibre of this herb is usually 1.3 mm in length. The stems of big sagebrush are usually harvested in the later part of summer, while the leaves are collected and the stems are steamed till the fiber can be stripped off. Subsequently, the fiber is cooked for as many as two hours with lye (a potent chemical cleaner) prior to ball milling for another four hours. The resulting product is the paper having a pale tan or golden color. Interestingly enough, the Native Americans also used the stems of big sagebrush as a broom. They tie a bunch of leafy stems together for this purpose. They also used the stems effectively as friction sticks for making fires. In addition, the shredded bark of the shrub is excellent tinder for starting fires. The seeds of big sagebrush are used during festivities, as when they are thrown in a fire, they burst out akin to crackers. The wood of big sagebrush shrubs is tough and dense and it burns very quickly and well, even when it is not dried, and possesses a fragrant smell.
Big sagebrush is among the most extensively distributed indigenous plants in the western regions of America. In addition, this plant is also found growing in British Columbia southwards to Mexico as well as to the Dakotas in the east. In order to grow and flourish well, big sagebrush needs to be cultivated in a sun-drenched and adequately drained soil that needs not be very rich in nutritional content. This woody shrub also needs a soil that is free of lime. In fact, there are some of the sub-species found growing in diverse habitats ranging from deep fertile soils to inferior shallow soils. When the plants grow in a poor dry soil, they live for longer periods, are very hardy and more aromatic. Big sagebrush plants that are already well established have the aptitude to tolerate drought. Although big sagebrush is able to endure temperatures as low as -5�C to -10�C, when grown in colder climatic regions plants of this species are not sufficiently hardy. Since the young plants growing in spring, as well as the young growths on mature plants, are susceptible to frost and, hence, it is advisable to grow big sagebrush in sheltered positions where they would not receive the early morning sun. The big sagebrush plants are extremely fragrant, particularly after rain. On the downside, the pollens of this plant are among the major reasons for causing hay fever in North America. It has been seen that generally the plants belonging to this genus are remarkable resilient to honey fungus. In addition, plants of this genus are seldom troubled by browsing deer. The big sagebrush plant is generally propagated by its seeds. It is best to sow the seeds between the later parts of winter to early summer in a greenhouse. While it is important to sow the seeds in a well-drained soil, you also should ensure that the compost does not dry out. A sub-species of big sagebrush called A. tridentata vaseyana have improved germination when their seeds are provided cool stratification for around 30 days to 50 days. The other sub-species of big sagebrush normally take one week to two weeks' time to germinate when the seeds are sown in a warm greenhouse. When the seedlings have grown sufficiently large to be handled, prick them out individually and plant them in separate pots. Continue growing the young plants in the greenhouse during their first winter and plant them in their permanent positions outdoors after the last expected frost of the winter is over. It is best to plant them outdoors during the later part of spring or in early summer. Big sagebrush can also be propagated through cuttings and division (during spring or autumn). If you wish to propagate the plant through the cutting method, cut half-matured wood of the shrub during July-August and plant them in a frame. It takes a very long time for the cuttings to give out roots.
Chemical analysis of the big sagebrush has revealed that it encloses terpenes, monoterpenes, carbohydrates, crude fats as well as a number of proteins.