Glyburide

Brand names of glyburide

  • Albert -Glyburide
  • Apo-Glyburide
  • Diabeta
  • Euglucon
  • Gen-Glybe
  • Glubate
  • Glynase Prestab
  • Micronase
  • Novo-Glyburide
  • Nu-Glyburide
  • PMS-Glyburide

Glyburide belongs to the class of drugs called sulfonylureas and is used to treat diabetes. Precisely speaking, this antidiabetes medication is given to individuals having high blood sugar (hyperglycemia) accompanied by type 2 diabetes.

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All antidiabetes drugs, including glyburide, are only prescribed when all other measures like diet, weight loss and exercise fail to bring the intensity of sugar in the bloodstream down to the desired level on their own. Glyburide works by augmenting the secretion of insulin - a hormone, which is made by the pancreas, enables sugar to go into the cells where it is required to generate energy, and facilitates the body to employ insulin with added efficiency.

Things you need to tell your physician before taking glyburide

As in the instance of any other prescription drugs, you need to tell your physician or pharmacist a few important things before you begin treatment with glyburide. First and foremost, you need to tell your physician if you have any allergic reaction to this medication, any of its elements or any other type of allergy. Glyburide may possibly enclose several inactive elements that may have the potential to cause allergies or additional problems. Therefore, if you are not sure about the contents of this antidiabetes medication, ask your pharmacist to provide you with a list of the ingredients of glyburide.

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In addition, you should not use glyburide provided you had or are suffering from some specific health conditions. Therefore, prior to using glyburide, you need to tell your physician or pharmacist whether you are suffering from any health condition related to metabolism, such as diabetic ketoacidosis. You should also tell your physician your entire medical history before using this medication, particularly if you are enduring any kidney or liver ailment; any particular hormonal conditions, such as SIADH-syndrome of inapt anti-diuretic hormone secretion or adrenal pituitary deficiency; thyroid disease; specific problems related to the nervous system, such as automatic neuropathy; and/ or electrolyte imbalance (hyponatremia). People taking glyburide may possibly experience blurred vision, drowsiness owing to very high or low levels of blood sugar, and/ or light-headedness.

As the use of glyburide may make you feel drowsy, it is advisable that you should not undertake any job that requires clear vision and alertness, such as driving or operating a machine, till you are certain about the effect of this medication on your body. At the same time, while undergoing treatment with glyburide, you need to restrict your alcohol consumption for alcohol is likely to augment the perils of developing hypoglycemia. Although alcohol seldom interacts with glyburide to result in grave side effects, such as a reaction like disulfiram accompanied with symptoms like nausea, reddening of the face, stomach ache, vomiting and dizziness, it is always advisable that you talk to your physician regarding how to use alcohol safely while taking glyburide. It may be noted that you may find it quite difficult to control your blood sugar levels when you are under strain or suffering from infections, fevers, injuries or have just undergone a surgery. In such situations you may possibly require a change in the medication and, hence, it is important that you consult your physician regarding your problems.

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People taking glyburide are likely to become more sensitive to exposure to sunlight. Therefore, it is advisable that they should avoid being in the sunlight for a long period, keep away from tanning booths and sunlamps. To a great extent, wearing protective clothes as well as using a sunscreen may help to overcome this problem. Elderly people using this drug should exercise additional caution, as they are more susceptible to the side effects of this antidiabetes medication. This medication should be given to pregnant women only when it is absolutely necessary for their condition. Instead of using glyburide, pregnant women may prefer taking insulin. However, if they are using glyburide, they should necessarily change to insulin at least two weeks prior to the expected date of childbirth for using glyburide may enhance the risks related to low blood sugar in the new born. It has been found that other medications belonging to the same class as glyburide pass onto the breast milk. Therefore, nursing mothers taking glyburide should essentially consult their physician prior to breast-feeding.

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Usage

Glyburide is an antidiabetes medication that is used to treat type 2 or non-insulin dependent diabetes that develops at the onset of adulthood. Occasionally, this medication is used in combination with added oral antidiabetes medications.

How to use glyburide

Glyburide is taken orally either along with your breakfast or when you are taking the first main meal of the day. Normally, this medication is taken only once every day, but you may also take it as per your physician's recommendation. In the instance of a number of diabetic patients, who are taking high doses of this antidiabetes drug, physicians may recommend taking this drug twice daily. Remember, the dosage of glyburide is entirely dependent on the medical condition of the patient as well as his/ her reaction to treatment.

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In order to obtain the utmost benefit of using glyburide, it is important to use this medication on a regular basis. Take this medication at the same time every day, as this will help you to remember when you should take it daily. In addition, keep an eye on your blood glucose levels periodically and tell your physician if the readings of the examinations of your blood glucose levels are extremely high or low.

How glyburide works

The antidiabetes medication glyburide works by inducing the discharge of insulin from the pancreas and, simultaneously, lessening the production of sugar in the liver.

Side effects

Serious:
Common:
Less common:

Possible interactions

Herbal medicines or minerals:
When used in conjunction, a number of herbal medicines and mineral supplements may interact with glyburide and, hence, they should never be used together. For instance, when people using glyburide also take chromium, it may possibly alter the manner, in which your body can utilize sugar. A number of stores selling health foods often promote the use of vanadium claiming that it imitates the working of insulin. However, currently, its use is prevented owing to possible toxicity as well as the requirement for more in depth studies regarding the use of this mineral. Here is a word of caution: use of this medication as well as the herb St. John's herb may both result in photosensitivity and, hence, they should never be used in conjunction.
Using the supplement DHEA (dehydroepiandrosterone) may possibly alter the patient's sensitivity to insulin or result in insulin resistance. In addition, herbs like garlic, ginger, hawthorn, ginseng, nettle, licorice and yohimbe have the aptitude to alter the levels of blood sugar. Therefore, it is important to consult your physician prior to taking any of these herbal medications in conjunction with glyburide, as this may need change in the dosage of hypoglycemic medicines. In addition, it is important to note that people with diabetes should never take blonde psyllium seed or husk or Echinacea purpurea injections.
Foods:
It is essential for people living with diabetes to strictly follow the diet prescribed by their physician.
Beverages:
As in the case of diet, diabetic patients should also only consume those beverages that have been directed by their physician.
Alcohol:
People with diabetes should exercise additional caution while using alcohol. They should always bear in mind that simultaneous use of alcohol has the potential to intensify the hypoglycemic actions of glyburide. In fact, using this antidiabetes medication may possibly result in a reaction akin to disulfiram, for instance, sweating profusely, facial flushing as well as palpitation.
Exposure to sun:
People taking glyburide become sensitive to exposure to sunlight and, hence, they need to exercise extreme caution until they are certain regarding the extent of their sensitivity to exposure to sun. In addition, a number of drugs belonging to the same class as glyburide may also result in photosensitivity.
Occurrence of unrelated illness:
Often development of other ailments not related to diabetes, such as diarrhea, vomiting, surgical procedures and even severe injuries, may result in the deterioration in controlling diabetes making it essential for the patients to use insulin. Contact your physician right away if you experience any of these conditions.

Discontinuation

It is advisable that people taking glyburide should assess the sustained benefit of using this medication once in every six months owing to the likelihood of developing a secondary failure.

Storage instructions

Glyburide should always be stored in the container it is available in. Seal the lid of the container securely and keep it in a place that is beyond the reach of children. It is important to store this medication at room temperature and in a dry place, away from excessive heat and dampness. Never store this medication in your bathroom, which is generally damp. When you do not require any medication or it has become outdated, dispose it in a proper and safe manner. Unless instructed otherwise, never dispose of the unwanted medication by flushing it down the toilet or pour it into a drain. It is advisable that you talk to your pharmacist or any local waste disposal company for further details.

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