Nadolol

Brand names of nadolol

  • Alti-Nadol
  • Apo-Nadol
  • Corgard
  • Corzide [CD]
  • Novo-Nadolol
  • Syn-Nadol

Nadolol is a beta-adrenergic receptor blocker and this drug is prescribed to treat hypertension (high blood pressure) as well as angina (heart/ chest pain). Atenolol (Tenormin), propanolol (Inderal LA, Inderal) and timolol (Blocadren) are a few other medications belonging to this class of drugs. It may be noted that epinephrine (adrenaline) and norepinephrine are two chemicals secreted in the body and they bind to the receptors on many types of cells, counting the nerve as well as a number of muscle cells. In addition, these chemicals also alter the manner of functioning of the cells, either by invigorating the cells or by means of repressing them. The beta-adrenergic receptor blocker nadolol obstructs the actions of epinephrine and norepinephrine, thereby lessening the heart rate, lowering the blood pressure and reducing the force with which the heart muscles contract by loosening up the muscles encircling the blood vessels.

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The heart's requirement for additional oxygen to cope with its workload becomes greater than what the blood is able to provide resulting in angina (heart pain). As nadolol retards the heart rate and also lessens the force with which the heart muscles contract, the heart's demand for oxygen is lessened and this, in turn, puts off the occurrence of angina. It may be noted that one downside of using beta-blockers is that they may make breathing difficult, as these medications result in the muscles encircling the air passages to tighten, which makes these air passages narrower and, at the same time, make the flow of air through these passages further difficult. Nadolol was approved by the Food and Drug Administration (FDA) for sale and use in the United States in 1979.

Things you need to tell your physician before taking nadolol

Before you take nadolol for the first time, it is important that you tell your physician as well as pharmacist whether you have any allergic reaction to this medication, any of its ingredients or any other drug. You ought to be aware of the fact that if you are allergic to various substances, your reactions may get worse while you are undergoing treatment with this medication. You should also know that consuming alcohol may augment the stupor, a common side effect of nadolol.

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In addition, you should also keep your physician and pharmacist informed regarding all the prescription and over-the-counter drugs, dietary supplements, vitamins and herbal products that you may be taking from before. In case you are using insulin or any oral medicine to treat diabetes and/ or reserpine, be sure that you tell your physician about it beforehand. In such instances, it is likely that your physician will require modifying the dose of your medications or supervise you cautiously to find if you develop any side effects owing to the use of nadolol.

Prior to beginning treatment with nadolol, it is also important to let your physician know about your entire medical history. You should especially tell your physician if you have ever suffered from or are still suffering from conditions like a sluggish heart rate; asthma or any different lung ailment; diabetes; diseases related to the heart or kidneys; serious allergies or hyperthyroidism (an overactive thyroid gland).

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Women who intend to take nadolol for their condition should ensure that they tell their physician if they are pregnant, are planning pregnancy or breast feeding. Call your physician right away in case you become pregnant while undergoing treatment with this medication.

In case you require undergoing any type of surgery, that includes any dental operation, you ought to inform your surgeon or dentist that you are already using nadolol.

Usage

The beta-adrenergic receptor blocker nadolol is prescribed for treating gentle to restrained hypertension (high blood pressure) as well as angina. In addition, this medication is also employed to put off or regulate irregular heartbeats (a condition known as arrhythmias).

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How to use nadolol

Nadolol should be taken strictly according to the prescription of your physician. Never take this medication in excessive or lower doses or for an extended period of time than what has been prescribed by your physician. In addition, you should also abide by the instructions on the prescription label.

It is likely that your physician may require modifying your dosage of the medication from time to time to ensure that you obtain the best results. In addition, you will be required to go for regular blood tests as well as additional tests at your physician's office. People taking nadolol should ensure that they visit their physician on a regular basis.

Also ensure that you do not miss any dose of nadolol or discontinue the medication all of a sudden and without consulting your physician. In fact, if you stop taking this medication abruptly, it may deteriorate your condition further.

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Provided you have to undergo any type of surgery, which may include a dental operation, you ought to tell your surgeon or dentist in advance that you are undergoing treatment with nadolol. It is possible that you will have to stop taking this medication for a brief period before, during and after the surgery.

People taking nadolol should know that this medicine may make it even more difficult for them to tell when their blood sugar level is low. In case you also have diabetes, you need to go for blood sugar tests at regular intervals. It is worth mentioning here that using nadolol may result in artificial results with specific urine tests in the laboratory.

Even if you start feeling better following few weeks' treatment with nadolol, you should continue taking this medication as per the instructions of your physician. Normally, people having high blood pressure do not have any symptoms of the condition. Most likely, you will be required to take medications for regulating your blood pressure for the remaining part of your life.

It ought to be noted that nadolol is just a part of a comprehensive program involving the treatment of high blood pressure, which may also incorporate appropriate diet, weight control and exercise. Therefore, it is important that you closely follow your medication schedule, diet as well as exercise routine, especially if you are taking this medication to treat hypertension.

How nadolol works

Nadolol works by retarding the pace as well as the strength at which the heart muscles contract by means of obstructing specific stimuli of the nerves. In this way, nadolol lowers high blood pressure. In addition, this medication facilitates the stabilization of the heart rhythm by altering the impulses sent by the nerves to the heart.

Side effects

Serious:
  • mental depression
  • pain or feelings of pressure or tightness in the chest
  • shortness of breath
  • slow or irregular heartbeat
  • swelling of the feet, ankles, and lower legs
  • wheezing
Common:
Less common:

Possible interactions

Herbal medicines or minerals:
Specific herbal remedies and minerals may interact with nadolol and, hence, they should never be used in conjunction. For instance, using ginseng is likely to raise the blood pressure, thereby diminishing the beneficial effects of this medication. Similarly, other herbs like saw palmetto, hawthorn, goldenseal, licorice, yohimbe, and ma huang may also result in an increase in blood pressure. On the other hand, garlic and calcium may perhaps lower high blood pressure. While Indian snakeroot possesses a German Commission E monograph indication for high blood pressure (hypertension), you should consult your physician prior to using this herb. People having high blood pressure should always try to keep away from the Siberian ginseng root.
Foods:
It is important that while undergoing treatment with nadolol you should strictly follow the diet prescribed by your physician. In addition, you ought to be careful to keep away from ingesting too much salt.
Alcohol:
Remember that consumption of alcohol may inflate the ability of nadolol to reduce blood pressure and, at the same time, may possibly augment the drug's gentle tranquilizing actions.
Tobacco smoking:
Smoking tobacco is not recommendable while you are taking nadolol, as nicotine has the aptitude to diminish the efficacy of this drug.
Exposure to heat:
People taking nadolol should be careful while exposing them to hot environs, as exposure to heat may reduce the blood pressure as well as inflate the actions of this medication.
Exposure to cold:
Similarly, exposure to cold environs may augment the deficiency of blood circulation in the extremities while you are undergoing treatment with nadolol. Aged adults taking this medication should especially take safety measures to put off the development of hypothermia.
Occurrence of unrelated illness:
Unrelated ailments like fever may reduce the blood pressure making it necessary for the patient to take lower doses of nadolol. Even vomiting and nausea may also interfere with the dosing of this medication. Therefore, it is advisable that you talk to your physician for advice and help in such situations.
Heavy exercise or exertion:
It will be wise if people undergoing treatment with nadolol stay away from undertaking rigorous activities that may cause extreme exhaustion, dizziness or cramps in the muscles.

Discontinuation

People using nadolol to treat high blood pressure should never discontinue this medication abruptly. It is advisable that before you stop taking nadolol, you should decrease its dose gradually over a period of two to three weeks.

Storage instructions

Nadolol should always be kept in the container in which you bought it. You need to seal the container firmly and keep it in a place that is not accessible to children. This medication should always be stored at room temperature and in a place that is free from extreme heat and dampness. Never store this medication in your bathroom, as it is mostly damp. All medications whose expiry date has lapsed or those which you do not require any more should be discarded in an appropriate and safe manner. You may consult your pharmacist or any neighbourhood waste disposal firm regarding the most appropriate way to dispose of such products.

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